Franziska K. Lorbeer

BARe-seq enables high-throughput dissection of cis-regulatory control of transcriptional bursting

BARe-seq measures transcriptional burst parameters in Drosophila cells using allele-resolved bulk sequencing, revealing distinct kinetic properties of promoters and enhancers.

A multispecies foundation model for genome function prediction, gene annotation and sequence design

NTv3 is a foundation model that predicts genome function, annotates genes, and designs DNA sequences across species, outperforming existing models in multiple tasks.

Programmatic design and editing of cis-regulatory elements

The paper introduces Ledidi, a computational method for designing cis-regulatory elements by optimizing continuous sequences guided by deep learning models, validated experimentally for controlling transcriptional outcomes.