Katharina Bergauer

BARe-seq enables high-throughput dissection of cis-regulatory control of transcriptional bursting

BARe-seq measures transcriptional burst parameters in Drosophila cells using allele-resolved bulk sequencing, revealing distinct kinetic properties of promoters and enhancers.

Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns

The paper shows that different promoter classes use distinct PIC compositions and mechanisms, leading to focused or dispersed transcription initiation patterns in Drosophila.

Identification and characterization of repressive domains in Drosophila transcription factors

The paper identifies and characterizes repressive domains in Drosophila transcription factors using a new high-throughput method, revealing conserved motifs and co-repressor interactions.