eSkip2 prioritizes exon-skipping antisense oligonucleotide target regions across exon--intron contexts
Shuntaro Chiba, Katsuhiko Kunitake, Satomi Shirakaki, Umme Sabrina Haque, Harry Wilton-Clark, Md Nur Ahad Shah, Jamie Leckie, Kosuke Matsui, Fumie Uno-Ono, Toshifumi Yokota, Yoshitsugu Aoki, Yasushi Okuno
eSkip2 identifies effective exon-skipping ASO target regions by integrating genomic context and splicing perturbations, outperforming exon-restricted models in prioritizing active regions.
bioRxiv · Aug 25, 2026 · PreprintBioinformatics