Author

Jennifer B. Jacob

Michigan State UniversityORCID 0000-0002-3173-2496Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Rui GengiD· 2 shared Ryann R Ray· 2 shared Benjamin Kidder· 1 shared Benjamin L. KidderiD· 1 shared Lisa PoliniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersCancer Biology

Rui GengORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 14, 2026

Early-onset spontaneous murine mammary tumors show increased lymphocyte representation and reduced MHC antigen presentation

Ryann R Ray, Lisa Polin, Rui Geng…·Jennifer B. Jacob

This study shows that introducing the PWK/PhJ genetic background in HER2/neu-driven breast cancer mice leads to earlier tumor onset, increased immune cell presence, and reduced MHC antigen presentation.

DOI 10.64898/2026.10.12.758076

mousescRNA-seq

Cancer BiologybioRxivPreprintOct 5, 2026

PWK genetic background reprograms heterochromatin and malignant epithelial states in Neu-driven mammary tumors

Rui Geng, Ryann R Ray, Jennifer B. Jacob, Benjamin L. Kidder

The paper shows that the PWK genetic background alters transcriptional programs, heterochromatin organization, and malignant epithelial state trajectories in NeuT mammary tumors.

DOI 10.64898/2026.10.01.755936

mousescRNA-seq