Lisa Polin

This study shows that introducing the PWK/PhJ genetic background in HER2/neu-driven breast cancer mice leads to earlier tumor onset, increased immune cell presence, and reduced MHC antigen presentation.

This paper develops a new compound KCI838 that selectively inhibits the AR-ELK1 axis in prostate cancer, showing potent anti-tumor activity in resistant models.

This study shows that combining Menin and XPO1 inhibitors synergistically inhibits KMT2A-r and NPM1-m AML cell growth and improves survival in xenograft models.

This study identifies CMTR1 as a cancer-related gene upregulated in multiple cancers, showing its role in ribosomal gene expression and tumor growth through multi-omics analysis and functional experiments.

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.