Author

Mohammed Salman Shazeeb

University of Massachusetts Chan Medical SchoolORCID 0000-0002-3175-8098Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Connor J. LewisiD· 3 shared Cynthia J. TifftiD· 3 shared Jean M. Johnston· 3 shared Maria T. AcostaiD· 3 shared Muhammad H. YousefiD· 3 shared Precilla D’SouzaiD· 3 shared Zeynep VardariD· 3 shared Anna Luisa KühniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Connor J. LewisORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

AAV9 Gene Therapy in GM1 Gangliosidosis Type II: A Phase 1/2 Trial

Connor J. Lewis, Precilla D’Souza, Jean M. Johnston, Maria T. Acosta, Cristan Farmer, Eva H. Baker, Anna Crowell, Yoliann Mojica Algarin, Sumaiya Ashraf, Lisa A. Joseph, Gilbert Vézina, Zenaide Quezado, Muhammad H. Yousef, Zeynep Vardar, Mohammed Salman Shazeeb, , Cynthia J. Tifft

This phase 1/2 trial evaluates AAV9 gene therapy for GM1 gangliosidosis Type II, showing safety and some biochemical and neuroimaging improvements.

New England Journal of Medicine · Feb 6, 2026Peer-reviewedGenetic & Genomic Medicine

A Case for Automated Segmentation of MRI Data in Milder Neurodegenerative Diseases

Connor J. Lewis, Jean M. Johnston, Precilla D’Souza, Josephine Kolstad, Christopher Thomas Zoppo, Zeynep Vardar, Anna Luisa Kühn, Ahmet Peker, Zubir Rentiya, Muhammad H. Yousef, William Allen Gahl, Mohammed Salman Shazeeb, Cynthia J. Tifft, Maria T. Acosta

This study evaluates automated MRI segmentation pipelines in GM1 gangliosidosis patients and controls, finding some methods comparable to manual segmentation for specific brain structures.

NeuroSci · Apr 3, 2025Peer-reviewedGenetic & Genomic Medicine

Differential Tractography: A Biomarker for Neuronal Function in Neurodegenerative Disease

Connor J. Lewis, Zeynep Vardar, Anna Luisa Kühn, Jean M. Johnston, Precilla D’Souza, Muhammad H. Yousef, William A. Gahl, Mohammed Salman Shazeeb, Cynthia J. Tifft, Maria T. Acosta

This study uses differential tractography to quantify white matter changes in GM1 patients and controls, showing degradation in patients and growth in controls, with correlations to clinical scores.

Brain Communications · Jan 1, 2025Peer-reviewedGenetic & Genomic Medicine