Author

Matthew T. Sipple

University of Rochester MedicineORCID 0000-0002-3194-2661Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:long-read sequencing· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

John D. LueckiD· 2 shared Charles A. ThorntoniD· 1 shared Christina S. HeiliD· 1 shared Joseph J. PorteriD· 1 shared Katherine M Lupia· 1 shared Katherine M. EdwardsiD· 1 shared Lily A. CiscoiD· 1 shared Peter MeinkeiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPhysiology

John D. LueckORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintSep 19, 2025

Elimination of myotonia improves myopathy in a muscleblind knockout model of myotonic dystrophy

Matthew T. Sipple, Sakura A. Hamazaki, Vanessa Todorow…·John D. Lueck

This study shows that removing a specific splice variant of ClC-1 in a DM1 mouse model eliminates myotonia and improves muscle function and histology.

DOI 10.1101/2025.09.19.677400

mouselong-read sequencing

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Molecular BiologyMolecular Therapy — Nucleic AcidsPeer-reviewedMay 4, 2022

Efficient Suppression of Endogenous CFTR Nonsense Mutations Using Anticodon Engineered Transfer RNAs

Wooree Ko, Joseph J. Porter, Matthew T. Sipple…·John D. Lueck

Anticodon engineered tRNAs suppress CFTR nonsense mutations, increasing mRNA expression and channel function in human cells.

74 citationstop 3%

humanexperimental assay

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