Multimodal AI Decodes Extreme Environment Functional Dark Matter Beyond Homology
Mengyang Xu, Dantong Wang, Qifan Liu, Hong Jiang, Xiaobin Liu, Yao Li, Di Wang, Hao Dong, Xinkai Yan, Yujing Liu, Anren Xu, Haidong Peng, Yanan Zhang, Hanbo Li, Shengying Li, , Xiangzhao Mao
The paper develops ACCESS, a multimodal graph neural network to annotate functional dark matter proteins from extreme environments beyond homology-based methods.
bioRxiv · Nov 15, 2025 · PreprintBioinformatics