Di Wang

LysM: a bacterial self-encoded peptidoglycan hydrolase as an antimicrobial and anti-biofilm agent for Gram-negative nosocomial pathogens

This paper identifies LysM, a bacterial enzyme with broad-spectrum antimicrobial and anti-biofilm activity against Gram-negative pathogens, and shows it can enhance antibiotic efficacy.

3D-MAESTRO: A scalable, modular, portable pipeline for automated processing of large-scale volumetric brain microscopy data

3D-MAESTRO automates processing of large-scale volumetric brain microscopy data, enabling scalable and reproducible analysis of mouse brain structures.

Chromosome-level genome assembly of the Northeast China Brown Frog (Rana dybowskii)

The paper presents a chromosome-level genome assembly for Rana dybowskii using PacBio HiFi and CiFi, achieving high completeness and gene prediction.

Prediction of Transcription Factor DNA Binding Affinity with High-Throughput Kd Measurements and Deep Learning

The paper introduces Seq2Kd, a deep learning model predicting TF-DNA binding affinity using high-throughput Kd measurements, and provides a web portal for functional genomics and disease research.

Topographic structure and function of locus coeruleus norepinephrine neurons

The paper identifies topographic organization in locus coeruleus norepinephrine neurons, linking their morphology, gene expression, and activity to specific brain regions and learning-related behaviors.

Multimodal AI Decodes Extreme Environment Functional Dark Matter Beyond Homology

The paper develops ACCESS, a multimodal graph neural network to annotate functional dark matter proteins from extreme environments beyond homology-based methods.