Targeted Genome Mining Discovery of the Ramoplanin Congener Chersinamycin from the Dynemicin-Producer Micromonospora chersina DSM 44154.
Kelsey T. Morgan, Jeffrey Zheng, Dewey Granville McCafferty
The paper identifies a new ramoplanin-like biosynthetic gene cluster in Micromonospora chersina and validates its function through CRISPR-Cas9 gene editing, leading to the discovery of the antibiotic chersinamycin.
bioRxiv · May 22, 2020 · PreprintBioinformatics