A pan-cancer atlas of transcriptional dependence on DNA methylation and copy number aberrations
Christian Fougner, Elen Höglander, Tonje Gulbrandsen Lien, Thérese Sørlie, Silje Nord, Ole Christian Lingjærde
The paper constructs a pan-cancer atlas showing how DNA methylation and copy number aberrations influence gene expression across cancers, finding that copy number changes drive heterogeneity and expression-methylation links are often due to cell-of-origin and normal cell mix.
bioRxiv · May 4, 2020 · PreprintGenomics