Ole Christian Lingjærde

The paper profiles immune cell composition in sentinel and axillary lymph nodes of breast cancer patients, finding T-cell exhaustion and immune changes associated with metastasis.

The paper introduces CANCAN, a computational framework for analyzing copy number and mutation heterogeneity in DNA sequencing data, showing high concordance with existing methods and improved performance on targeted sequencing data.

StarSignDNA is an algorithm for mutational signature analysis in cancer sequencing data, improving accuracy and biological validity by addressing overfitting and underfitting.

The paper identifies cis-regulatory mutations in cancer that disrupt gene regulatory programs by affecting both transcriptional and post-transcriptional regulation.

The paper constructs a pan-cancer atlas showing how DNA methylation and copy number aberrations influence gene expression across cancers, finding that copy number changes drive heterogeneity and expression-methylation links are often due to cell-of-origin and normal cell mix.

The paper identifies copy number motifs in breast cancer genomes that predict disease outcome and driver events, outperforming existing clinical and genomic markers.