Thérese Sørlie

The paper constructs a pan-cancer atlas showing how DNA methylation and copy number aberrations influence gene expression across cancers, finding that copy number changes drive heterogeneity and expression-methylation links are often due to cell-of-origin and normal cell mix.

The paper identifies claudin-low-like mouse mammary tumors with transcriptomic similarities to human claudin-low breast cancer, but no specific genomic drivers distinguish them.