This study creates a single-cell and spatially resolved atlas of human esophageal squamous cell carcinoma, identifying key tumor and fibroblast subgroups and their interactions in the tumor microenvironment.

Genomics Proteomics & Bioinformatics · Nov 4, 2025Peer-reviewedGenomics

STASCAN deciphers fine-resolution cell-distribution maps in spatial transcriptomics by deep learning

Ying Wu, Jiayi Zhou, Bofei Yao, Guanshen Cui, Yongliang Zhao, Chun‐Chun Gao, Ying Yang, Shihua Zhang, Yun‐Gui Yang

STASCAN improves spatial transcriptomics resolution by combining gene expression and histology images, revealing finer cell structures across species and tissues.

Genome biology · Oct 22, 2024Peer-reviewedBioinformatics

m6A-mediated Cell-cell Communication Controls Planarian Regeneration

Guanshen Cui, Jiayi Zhou, Xin-Yang Ge, Baofa Sun, Gege Song, Xing Wang, Xiuzhi Wang, Rui Zhang, Hailin Wang, Qing Jing, Yongliang Zhao, Magdalena J. Koziol, An Zeng, Weiqi Zhang, Dali Han, , Yun‐Gui Yang

This study shows that m6A-mediated cell-cell communication is essential for planarian regeneration, as disrupting m6A methyltransferase leads to regeneration failure.

bioRxiv · Jul 29, 2021 · PreprintMolecular Biology