A Human Next Generation PBK Model for PFOA
Chrysanthi Pachoulide, Carolina Vogs, Aude Ratier, Jack Koster, Trine Husøy, Martine Vrijheid, Yiyi Xu, Antonios Georgelis, Karl Forsell, Joost Westerhout, Nynke I. Kramer
This paper develops a mechanistic NG-PBK model for PFOA using in vitro and in silico data, showing it accurately predicts toxicokinetics and can be extrapolated to other PFAS for risk assessment.
Environment International · Feb 27, 2026Peer-reviewedPharmacology & Toxicology