Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction
Daniel Auguin, Julien Robert‐Paganin, S. Réty, Carlos Massayuki Kikuti, Amandine David, Gabriele Theumer, Arndt W. Schmidt, Hans‐Joachim Knölker, Anne Houdusse
This study shows Omecamtiv mecarbil and Mavacamten target the same myosin pocket but have antagonistic effects on heart contraction through structural and simulation analyses.
bioRxiv · Nov 15, 2023 · PreprintMolecular Biology