Author

Hans‐Joachim Knölker

Centre for Biomedical Network Research on Rare DiseasesORCID 0000-0002-9631-5239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:mouse· 1

Frequent Co-Authors

Adam AntebiiD· 1 shared Agustín LahoziD· 1 shared Alex ZaufeliD· 1 shared Amandine DavidiD· 1 shared Ana Pilar Gómez-EscribanoiD· 1 shared Anna Löhrke· 1 shared Anne HoudusseiD· 1 shared Arndt W. Schmidt· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperGenetics

Adam AntebiORCID

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3 papers

Recent·Most cited

mTOR regulates longevity through a bile-acid like hormonal mechanism and DHS- 26/DHRS1

Klara Schilling, Alex Zaufel, Kaylee M Morris, Anna Löhrke, Ratni Saini, Hans‐Joachim Knölker, Tarek Moustafa, Adam Antebi

This study identifies mTOR's role in longevity through a bile-acid-like hormonal mechanism involving DHS-26/DHRS1 in C. elegans and mammals.

bioRxiv · May 17, 2026 · PreprintGenetics

Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction

Daniel Auguin, Julien Robert‐Paganin, S. Réty, Carlos Massayuki Kikuti, Amandine David, Gabriele Theumer, Arndt W. Schmidt, Hans‐Joachim Knölker, Anne Houdusse

This study shows Omecamtiv mecarbil and Mavacamten target the same myosin pocket but have antagonistic effects on heart contraction through structural and simulation analyses.

bioRxiv · Nov 15, 2023 · PreprintMolecular Biology

Opposing steroid signals modulate protein homeostasis through deep changes in fat metabolism in Caenorhabditis elegans

Ana Pilar Gómez-Escribano, Carlos Mora‐Martínez, Marta Roca, DS Walker, Joaquín Panadero, María Dolores Sequedo, R Saini, Hans‐Joachim Knölker, José Blanca, Juan Andrés Burguera, Agustín Lahoz, Joaquı́n Cañizares, JM Millán, Nicholas O. Burton, William R Schafer, Rafael P. Vázquez‐Manrique

The paper shows that UNC-1 in C. elegans neurons modulates protein homeostasis by altering fat metabolism through neurohormonal signaling involving NHR-1 and DAF-12.

bioRxiv · Dec 8, 2021 · PreprintGenetics