Author
Broad InstituteORCID 0000-0002-3295-1164Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Srinivas Niranj Chandrasekaran, Eric Alix, John Arévalo…·Anne Elizabeth Carpenter
The paper presents a comprehensive genetic perturbation dataset using Cell Painting to analyze gene expression effects in human cells, revealing novel gene clusters and functional relationships.
Srinivas Niranj Chandrasekaran, Beth A. Cimini, Amy B. Goodale…·Anne Elizabeth Carpenter
The paper introduces a dataset of cell morphology images treated with matched chemical and genetic perturbations and evaluates methods for identifying perturbation similarities.
Beth A. Cimini, Srinivas Niranj Chandrasekaran, Maria Kost‐Alimova…·Anne Elizabeth Carpenter
The paper updates the Cell Painting assay protocol to improve morphological profiling, finding that simplified steps and reduced stain concentrations maintain robust outputs.
Srinivas Niranj Chandrasekaran, Jeanelle Ackerman, Eric Alix…·Anne Elizabeth Carpenter
Cell Painting images and profiles for 115,796 compounds in U2OS cells from 12 laboratories; 15.2% of analyzed compounds are phenotypically active, and cross-laboratory replicates cut reference-compound activity by 34%.