Maria Kost‐Alimova

This study identifies a therapeutic target, the entrapment complex, that clears toxic protein accumulation in distinct proteinopathies by disrupting a cargo receptor complex.

This study evaluates alternative dyes for image-based profiling assays, finding that some substitutions maintain performance while enabling live-cell imaging and expanded feature space.

The paper presents a comprehensive genetic perturbation dataset using Cell Painting to analyze gene expression effects in human cells, revealing novel gene clusters and functional relationships.

This study identifies FAF2 as a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses through a CRISPR knockout screen in human cells.

The paper introduces a dataset of cell morphology images treated with matched chemical and genetic perturbations and evaluates methods for identifying perturbation similarities.

The paper updates the Cell Painting assay protocol to improve morphological profiling, finding that simplified steps and reduced stain concentrations maintain robust outputs.

The paper introduces LipocyteProfiler, a high-throughput microscopy assay to profile lipid-storing cells and identifies cellular programs linked to metabolic traits like insulin resistance and lipodystrophy.

Cell Painting images and profiles for 115,796 compounds in U2OS cells from 12 laboratories; 15.2% of analyzed compounds are phenotypically active, and cross-laboratory replicates cut reference-compound activity by 34%.

The paper compares morphology and gene expression data to determine their complementary roles in mapping cell states across drug perturbations.

This study identifies Sp7 and its target gene osteocrin as critical for osteocyte dendrite formation and shows their role in human skeletal diseases.

The paper develops a method to predict cell health phenotypes from Cell Painting images using machine learning, validated across multiple perturbations and assays.

The paper uses single-cell RNA-Seq to assess kidney organoid reproducibility across iPSC lines and shows transplantation reduces off-target cells.