TRPC6-Mediated Ca2+ Influx Activates MAPK and NF κB Signaling and Elicits Pro-Inflammatory and Catabolic Responses in Human Intervertebral Disc Cells
Janitri Venkatachala Babu, Varun Puvanesarajah, Addisu Mesfin, Jonathan P. Japa, Kevin Yoon, Mark Ehioghae, Michael G. Schrlau, Laura S. Stone, Wolfgang Hitzl, Karin Wuertz‐Kozak
This study shows TRPC6 activation in human intervertebral disc cells causes calcium influx and activates MAPK and NF-κB pathways, leading to inflammation and catabolic responses.
Cells · Mar 17, 2026Peer-reviewedMolecular Biology