Wolfgang Hitzl

TRPC6-Mediated Ca2+ Influx Activates MAPK and NF κB Signaling and Elicits Pro-Inflammatory and Catabolic Responses in Human Intervertebral Disc Cells

This study shows TRPC6 activation in human intervertebral disc cells causes calcium influx and activates MAPK and NF-κB pathways, leading to inflammation and catabolic responses.

Development and Characterization of a Tunable PDMS Substrate Model for Investigating Elastic Properties and Mechanical Stretching in Intervertebral Disc Cells

This paper develops a tunable PDMS substrate platform to study mechanical loading and cell-substrate interactions in intervertebral disc cells, showing cells align with applied strain and maintain viability.

Early Disruption of Photoreceptor Cell Architecture and Loss of Vision in a Humanized Pig Model of Usher Syndrome

This study creates a humanized pig model of Usher syndrome type 1, showing disrupted photoreceptor architecture and vision loss, and validates gene therapy approaches.