Identification of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir
Laura Krismer, Helge Schöppe, Stefanie Rauch, David Bante, Bernhard Sprenger, Andreas Naschberger, Francesco Costacurta, Anna Fürst, Anna Sauerwein, Bernhard Rupp, Teresa Kaserer, Dorotheé von Laer, Emmanuel Heilmann
The paper evaluates the effectiveness of SARS-CoV-2 protease inhibitors against MERS-CoV proteases and identifies resistance mechanisms.
npj Viruses · Jun 24, 2024Peer-reviewedMolecular Biology