Identification of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir
Laura Krismer, Helge Schöppe, Stefanie Rauch…·Emmanuel Heilmann
The paper evaluates the effectiveness of SARS-CoV-2 protease inhibitors against MERS-CoV proteases and identifies resistance mechanisms.