Author

Mercedes Machuca-Ostos

The Netherlands Cancer InstituteORCID 0000-0002-3321-4940Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Anne M. van der LeuniD· 1 shared Daniela S. ThommeniD· 1 shared Eline RunderkampiD· 1 shared Ivana M. DjureticiD· 1 shared Janniek R. MorsiD· 1 shared Kelly Dare MoynihaniD· 1 shared Nadine SlingerlandiD· 1 shared Paulien KapteiniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Anne M. van der LeunORCID

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintSep 24, 2025

Reinvigoration of translational activity in dysfunctional T cells initiates theearly intratumoral response to PD-1 blockade

Paulien Kaptein, Nadine Slingerland, Anne M. van der Leun…·Daniela S. Thommen

The paper shows that PD-1 blockade reinvigorates dysfunctional T cells by restoring translational activity, driving early antitumor immune responses in tumors.

2 citations

humanbulk RNA-seq

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