Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice
Md Marzan Sarkar, Nathan Gonsalves, Amin Davarzani, Emma Mitchell, Amar M. Singh, Lohitash Karumbaiah, Steven L. Stice
This study shows that inhibiting Akt with MK-2206 suppresses glioblastoma growth and progression in mice, outperforming a β-catenin inhibitor in vitro and in vivo.
Journal of Neuro-Oncology · Mar 1, 2026Peer-reviewedCancer Biology