BioinformaticsComputational and Structural Biotechnology JournalPeer-reviewed
Integrative modeling of read depth and B-allele frequency improves single-cell copy number calling from targeted DNA sequencing panels
Dong Pei, Rachel Griffard-Smith, Brahian Cano Urrego, Emily Schueddig
The paper introduces scPloidyR, a hidden Markov model that jointly models read depth and B-allele frequency for improved single-cell copy number calling from targeted DNA sequencing, showing better performance when allelic information is available.
DOI 10.34133/csbj.0203