Integrative modeling of read depth and B-allele frequency improves single-cell copy number calling from targeted DNA sequencing panels
Dong Pei, Rachel Griffard-Smith, Brahian Cano Urrego, Emily Schueddig
The paper introduces scPloidyR, a hidden Markov model that jointly models read depth and B-allele frequency for improved single-cell copy number calling from targeted DNA sequencing, showing better performance when allelic information is available.
Computational and Structural Biotechnology Journal · Mar 1, 2026Peer-reviewedBioinformatics