Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease
Akihiro Nomura, Connor A. Emdin, Hong‐Hee Won, Gina Marie Peloso, Pradeep Natarajan, Diego Ardissino, John Danesh, Heribert Schunkert, Adolfo Correa, Matthew J. Bown, Nilesh J. Samani, Jeanette Erdmann, Ruth McPherson, Hugh C Watkins, Danish Saleheen, , Sekar Kathiresan
This study investigates the impact of heterozygous ABCG5 LoF variants on LDL-C levels and CAD risk, finding a significant association with elevated LDL-C and doubled CAD risk.
Circulation Genomic and Precision Medicine · Aug 30, 2020Peer-reviewedGenetics