Hong‐Hee Won

This study performs a trans-ancestry GWAS of SSRI response in depression, finding suggestive associations and enrichment in serotonergic pathways but no genome-wide significant variants.

SingleBrain integrates snRNA-seq and genotype data to map cis-eQTLs across brain cell types, identifying novel disease-associated genes and causal variants.

The paper identifies 38,731 edQTLs in 3,554 genes through a meta-analysis of A-to-I RNA editing in the human brain and links 24 GWAS loci for neurological disorders to edQTLs.

The paper maps genetic effects on splicing in 10,725 brain samples, identifying 68,358 cis-sQTLs and 97 loci where splicing mediates neurological disease risk.

The paper finds that mosaic chromosomal alterations in blood are associated with increased Alzheimer's disease risk, with variations by ancestry, mCA subtype, APOE ε4 status, and chromosomal location.

The paper presents AIDA, a diverse single-cell RNA-seq atlas of immune cells, revealing sub-continental diversity impacts on immune cell properties and identifying functional genetic variants.

The paper constructs a tissue-level phenome-wide network map linking genes and phenotypes using colocalized signals from the UK Biobank and Genotype-Tissue Expression project.

This study performs a GWAS on creativity using 241,736 individuals, identifying 25 loci and showing genetic overlap with several psychiatric disorders.

This paper introduces PRS-CSx, a method that improves polygenic prediction across ancestrally diverse populations by integrating GWAS summary statistics and sharing genetic effects.

This paper introduces netCRS, a network-based comorbidity risk score that improves myocardial infarction prediction using PheWAS data, achieving better AUC than traditional PRS methods.

Meta-analysis of 41,917 European-ancestry bipolar disorder cases versus 371,549 controls yields 64 risk loci (33 novel), neuronal and synaptic gene enrichment, and 15 eQTL-prioritized genes.

This study uses Mendelian randomization to assess if CSF biomarkers for amyloid and tau pathology causally influence Alzheimer’s disease risk, finding a protective effect for Aβ and a risk increase for p-tau.

This study investigates the impact of heterozygous ABCG5 LoF variants on LDL-C levels and CAD risk, finding a significant association with elevated LDL-C and doubled CAD risk.

The paper identifies homozygous null mutations in 961 genes in a consanguineous Pakistani cohort and reports their phenotypic consequences.

This paper introduces LDpred, a method that improves polygenic risk score accuracy by modeling linkage disequilibrium, showing increased R2 values in schizophrenia and multiple sclerosis datasets.