Author

Ruth McPherson

Ottawa Heart InstituteORCID 0000-0002-9087-6107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:GWAS / association mapping· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Amit V. KheraiD· 2 shared Connor A. EmdiniD· 2 shared Danish SaleheeniD· 2 shared Diego ArdissinoiD· 2 shared Heribert SchunkertiD· 2 shared Hugh C WatkinsiD· 2 shared Jeanette ErdmanniD· 2 shared John DaneshiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Amit V. KheraORCID

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4 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 26, 2026

Exon Resolved Dissection of Shared, Unique, and Antagonistic Functions of ZFAS1 Isoforms

Sébastien Soubeyrand, Paulina Lau, Ruth McPherson

The paper examines the functional differences of ZFAS1 isoforms by targeting specific exons and identifies shared and antagonistic effects on cell cycle and translation.

DOI 10.64898/2026.05.22.727302

humanbulk RNA-seq

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Cell BiologyPLoS ONEPeer-reviewedSep 2, 2025

Deciphering the role of the lncRNA TRIBAL in hepatocyte models

Sébastien Soubeyrand, Paulina Lau, Ruth McPherson

The paper validates HepaRG cells as a model for studying TRIBAL, showing functional overlap with hepatocytes and highlighting TRIBAL's role in metabolic regulation.

1 citation

humanbulk RNA-seq

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GeneticsCirculation Genomic and Precision MedicinePeer-reviewedAug 30, 2020

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease

Akihiro Nomura, Connor A. Emdin, Hong‐Hee Won…·Sekar Kathiresan

This study investigates the impact of heterozygous ABCG5 LoF variants on LDL-C levels and CAD risk, finding a significant association with elevated LDL-C and doubled CAD risk.

78 citationstop 1%

humanstatistical model

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GenomicsPLoS GeneticsPeer-reviewedApr 13, 2020

A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease

Connor A. Emdin, Mary E. Haas, Amit V. Khera…·Sekar Kathiresan

The paper identifies a missense variant in the MARC1 gene associated with protection against cirrhosis and lower liver enzyme and cholesterol levels.

160 citationstop 1%

humanGWAS summary statistics

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