Heribert Schunkert

The paper develops a proteomic aging clock using longitudinal plasma proteomics data to show that biological aging is dynamically influenced by modifiable risk factors.

This study develops a monoclonal antibody against ADAMTS-7 that reduces atherosclerosis in mice without affecting lipid levels or causing toxicity.

The paper presents results from an open competition to develop aging biomarkers using DNA methylation data, showing improved predictive models for age, mortality, and multi-morbidity.

The paper constructs a cell type-resolved proteomic atlas of the human body using Deep Visual Proteomics, revealing protein abundance patterns and uncovering cancer-testis antigens in oocytes.

This study investigates how ZC3HC1 deficiency affects vascular smooth muscle cell behavior and neointima formation using in vitro and in vivo models.

The paper identifies 1,580 cell type-specific genes and non-coding RNAs associated with coronary artery disease by integrating genetic and epigenetic data from multiple cell types.

This study shows cancer increases atherosclerotic plaque vulnerability through pathological angiogenesis, and targets this pathway to prevent plaque destabilization.

This study shows cigarette smoke increases vascular ADAMTS7 expression through CCL17-CCR4 signaling, linking smoking to atherosclerosis via a novel gene-environment interaction.

This study identifies novel and known genetic contributors to hypertension using RNA-seq and eQTL analyses, highlighting potential drug targets and pathways.

This study shows that a polygenic risk score for coronary artery disease is associated with more severe atherosclerosis features in autopsy samples of sudden death cases.

This study identifies ADAMTS-7 as a risk factor for atherosclerosis by degrading TIMP-1, reducing its inhibition of MMP-9 and promoting collagen degradation.

This study uses transcriptome-wide association analysis to identify 114 genes associated with coronary artery disease, including 18 novel genes, and shows they are enriched in lipid metabolism pathways.

A coronary artery disease GWAS of 181,522 cases among 1,165,690 participants yields 241 associations (54 new); an eight-predictor consensus nominates 185 candidate causal genes, 94 with ≥3 predictors.

This study investigates the impact of heterozygous ABCG5 LoF variants on LDL-C levels and CAD risk, finding a significant association with elevated LDL-C and doubled CAD risk.

The paper identifies a missense variant in the MARC1 gene associated with protection against cirrhosis and lower liver enzyme and cholesterol levels.

This study identifies a genome-wide significant association between a variant in the KCND3 gene and early repolarization pattern on ECG, suggesting a genetic basis for this trait.

The paper identifies cis-epistasis at the LPA locus involving two SNPs that interact to modulate coronary artery disease risk and related traits.

This paper introduces B-LORE, a Bayesian multiple logistic regression method for GWAS, showing improvements in detecting disease-associated SNPs in heritable traits and unbalanced case-control ratios.