Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences
Sushant Kumar, Jonathan Warrell, Shantao Li, Patrick D. McGillivray, William U. Meyerson, Leonidas Salichos, Arif O. Harmanci, Alexander Martinez‐Fundichely, Calvin Wing Yiu Chan, Morten Muhlig Nielsen, Lucas Lochovsky, Yan Zhang, Xiaotong Li, Jakob Skou Pedersen, Carl Herrmann, , Mark Gerstein
The paper analyzes 2500 cancer genomes to assess the molecular functional impact of mutations, finding that some putative passenger variants may influence gene activity and contribute to cancer phenotypes.
bioRxiv · Mar 12, 2018 · PreprintGenomics