Author

Calvin Wing Yiu Chan

German Cancer Research CenterORCID 0000-0002-3656-7709Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 5 Approach:statistical model· 5 Assay:whole-genome sequencing· 4 Research Focus:gene regulatory network inference· 3 Research Focus:database / resource· 2 Research Focus:differential expression· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Carl HerrmanniD· 5 shared Ekta KhuranaiD· 4 shared Gad A. GetziD· 4 shared Jakob Skou PederseniD· 4 shared Lucas LochovskyiD· 4 shared Mark GersteiniD· 4 shared Morten Muhlig NielseniD· 4 shared Abdullah KahramaniD· 3 shared

Activity by Year

2017-2020 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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5 shared papersGenomics

Carl HerrmannORCID

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Author profile →

5 papers

Recent·Most cited

Unique genomic features and deeply-conserved functions of long non-coding RNAs in the Cancer LncRNA Census (CLC)

Joana Carlevaro-Fita, Andrés Lanzós, Lars Feuerbach, Chen Hong, David Mas-Ponte, Jakob Skou Pedersen, PCAWG Drivers and Functional Interpretation Group, Federico Abascal, Samirkumar B. Amin, Gary D. Bader, Jonathan Barenboim, Rameen Beroukhim, Johanna Bertl, Keith A. Boroevich, Søren Brunak, , S. Cenk Şahinalp

The paper introduces the Cancer LncRNA Census (CLC), a curated resource of lncRNAs with causative roles in cancer, and shows their genomic and evolutionary features.

Communications Biology · Feb 5, 2020Peer-reviewedGenomics

Integrative pathway enrichment analysis of multivariate omics data

Marta Paczkowska, Jonathan Barenboim, Nardnisa Sintupisut, Natalie S. Fox, Helen Zhu, Diala Abd-Rabbo, Miles W. Mee, Paul Christopher Boutros, PCAWG Drivers and Functional Interpretation Working Group, Federico Abascal, Samirkumar B. Amin, Gary D. Bader, Rameen Beroukhim, Johanna Bertl, Keith A. Boroevich, , Leonidas Salichos

ActivePathways integrates multivariate omics data to identify enriched pathways, revealing cancer driver genes and prognostic pathways in breast cancer.

Nature Communications · Feb 5, 2020Peer-reviewedBioinformatics

Impact of cancer mutational signatures on transcription factor motifs in the human genome

Calvin Wing Yiu Chan, Zuguang Gu, Matthias Bieg, Roland Eils, Carl Herrmann

The paper links cancer mutational signatures to changes in transcription factor binding site motifs, showing correlations between motif alteration and signature information content.

BMC Medical Genomics · May 20, 2019Peer-reviewedBioinformatics

Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences

Sushant Kumar, Jonathan Warrell, Shantao Li, Patrick D. McGillivray, William U. Meyerson, Leonidas Salichos, Arif O. Harmanci, Alexander Martinez‐Fundichely, Calvin Wing Yiu Chan, Morten Muhlig Nielsen, Lucas Lochovsky, Yan Zhang, Xiaotong Li, Jakob Skou Pedersen, Carl Herrmann, , Mark Gerstein

The paper analyzes 2500 cancer genomes to assess the molecular functional impact of mutations, finding that some putative passenger variants may influence gene activity and contribute to cancer phenotypes.

bioRxiv · Mar 12, 2018 · PreprintGenomics

Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes

Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Pedersen, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Lynge Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, , Gad A. Getz

The paper identifies and characterizes coding and non-coding driver mutations across 2,500 cancer genomes, revealing new candidates and questioning previous findings.

bioRxiv · Dec 23, 2017 · PreprintGenomics