Yan Zhang

Dynamic allocation of MurJ coordinates bacterial growth and division

The paper shows that MurJ, a Lipid II flippase, dynamically coordinates bacterial growth and division by transiently capturing at division sites during septal synthesis.

Cellular composition and the interpretation of candidate RNA readouts of trogocytosis in colorectal cancer

The paper evaluates an eight-gene module associated with trogocytosis in CRC, finding its correlation with T-cell fraction is typical of random modules, suggesting it reflects cellular composition rather than trogocytosis.

Scaling genetic discovery through automated post-GWAS interpretation

This paper introduces PGI, a system that automates post-GWAS interpretation, achieving high recovery of findings and enabling cross-study biological evidence accumulation.

Live imaging reveals oocyte membrane pre-remodeling forming permissive space for asymmetric division

The paper uses live imaging to show that mouse oocytes undergo membrane remodeling to create a pre-extrusion space for polar body extrusion, regulated by ERK-ZO-1 signaling.

The RNA-binding protein TRIM71 Promotes Supporting Cell Reprogramming and Hair Cell Regeneration by Activating Sall4

This study shows TRIM71 promotes hair cell regeneration by reprogramming supporting cells and activating Sall4 in cochlear organoids and explants.

Single-Atom Modification Enables Reversal of Degradation Selectivity between NSD2 and GSPT1

This study modifies a molecule to create two variants with different target selectivity, showing how small structural changes can control degradation activity.

Inflammation-induced of Clec18a inhibits immune responses via Trpm7-dependent Cbl activation

This study identifies Clec18a as a regulator of innate immune responses by inhibiting inflammation through Trpm7-dependent Cbl activation.

cryoAgent: An agentic workflow for robust and adaptive end-to-end cryo-EM image processing

cryoAgent improves cryo-EM image processing by enabling autonomous, adaptive workflows that enhance reconstruction quality and identify new structural states.

Spatiotemporally distinctive astrocytic and neuronal responses to repetitive intracortical microstimulation

This study shows that astrocytes and neurons respond differently to intracortical microstimulation, with astrocytes showing spatially heterogeneous and temporally variable responses.

A telomere-to-telomere (T2T) pig genome assembly reveals Y chromosome diversity and structural variations of Wuzhishan pigs

This study assembles a high-quality telomere-to-telomere genome of Wuzhishan pigs, revealing genetic diversity and structural variations compared to a previous assembly.

Multi-omics Profiling Identifies Molecular and Cellular Signatures of Regular Physical Activity in Human Peripheral Blood

This study identifies molecular and cellular signatures of regular physical activity in human peripheral blood using multi-omics profiling, revealing enhanced metabolic and immune functions.

Genome-wide cross-trait analysis of vascular dementia and Alzheimer's disease highlights novel loci and lung-brain axis

This study identifies novel genetic loci for vascular dementia and its association with lung function, and finds shared genetic risk factors with Alzheimer's disease.

Single-Cell and Spatial Transcriptomic Analyses Reveals the Dynamic Transcript Profiles of Myocardial Lymphangiogenesis post Myocardial Infarction

This study integrates single-cell and spatial transcriptomic data from mouse hearts post-myocardial infarction to identify functionally distinct lymphatic endothelial cell subtypes and their roles in tissue repair and inflammation.

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

Galvanotactic directionality of cell groups depends on group size

This study shows that galvanotactic directionality of cell groups depends on group size and internal cell signaling, with small PI3K-inhibited groups moving to the anode and larger ones to the cathode.

Improving the value utilization of tuna peptide powder for the cosmetics field through ozone oxidation

This study uses ozone oxidation to deodorize tuna peptide powder for cosmetics, finding optimal conditions that reduce fishy smell without affecting protein activity.

Receptor Allostery Promotes Context-Specific Sonic Hedgehog Signaling During Embryonic Development

This study identifies an arachidonic acid binding pocket in SMO that modulates SHH signaling, revealing context-specific allostery crucial for cardiopulmonary development.

Multi-omics Reveals Immune Response and Metabolic Profiles during High-Altitude Mountaineering

This study uses multi-omics data to analyze immune and metabolic changes in mountain climbers during acclimatization and extreme altitude exposure.

Gut Microbiota and DTI Microstructural Brain Alterations in Rodents Due to Morphine Self-Administration

This study shows that morphine self-administration in rodents alters gut microbiota and brain microstructure, with neuroinflammation linking gut and brain changes.

F-CPI: Prediction of activity changes induced by fluorine substitution using multimodal deep learning

This study introduces F-CPI, a deep learning model to predict activity changes from fluorine substitution in drugs, achieving 89% accuracy and demonstrating its utility in optimizing SARS-CoV-2 3CLpro inhibitors.

Detection of early-onset severe preeclampsia by cell-free DNA fragmentome

This paper develops a machine-learning model using cfDNA fragmentation patterns to predict early-onset severe preeclampsia with high accuracy in early pregnancies and NIPT samples.

Tight junction component protein claudin-1 deficiency in retinal pigment epithelium leads to early and intermediate age-related macular degeneration phenotypes in mice.

This study shows that claudin-1 deficiency in mouse retinal pigment epithelium leads to AMD-like phenotypes including drusenoid deposits and pigment abnormalities.

Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data

The paper introduces scPagwas, a method that integrates pathway activation transformation of scRNA-seq data with GWAS summary statistics to identify trait-relevant cell populations and pathways.

A glutamatergic DRN-VTA pathway for neuropathic pain and comorbid depression-like behavior modulation

This study identifies a glutamatergic pathway from VGluT3DRN to DAVTA that modulates neuropathic pain and depression-like behavior through DA release in the NAcMed.

The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic pain

This study identifies an inhibitory circuit between the thalamic reticular nucleus and lateral habenula that modulates depressive-like behaviors in chronic stress and pain.

Cdh5-lineage independent origin of dermal lymphatic vessels revealed by temporally restricted lineage tracing

The paper uses lineage tracing to show that dermal lymphatic vessels can originate from sources other than the Cdh5 lineage, highlighting the importance of temporal control in lineage tracing.

The genome sequence of Sorbus pohuashanensis provides insights into population evolution and leaf sunburn response

This paper reports the genome of Sorbus pohuashanensis, identifies genetic diversity and evolutionary patterns, and links gene families to sunburn response.

Synthetic genome rearrangement reveals dynamics of chromosome evolution shaped by hierarchical chromatin organization

This study uses synthetic genome rearrangement to show that chromatin organization influences the frequency and spatial distribution of genome structural variations in yeast.

Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic-terrestrial transition

This study analyzes the genomes of giant African snails to investigate whole-genome duplication and adaptations to terrestrial environments.

scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures

scTPA provides a web tool for analyzing single-cell RNA-seq data using pathway activation signatures to annotate cell types and identify functional patterns.