Targeting the Tumor-Stroma Crosstalk: An AI-Based Virtual Screening Strategy for Dual MET/SMO Inhibitors in Pancreatic Cancer
Michele Roggia, Ugo Chianese, Giorgio Amendola, Valentina Albanese, Cinzia Vetrei, Caterina Ieranò, Crescenzo D’Alterio, Salvatore Di Maro, Fortunato Ciardiello, Floriana Morgillo, Stefania Scala, Lucia Altucci, Delia Preti, Gunnar Schulte, Rosaria Benedetti, , Sandro Cosconati
An AI-identified dual SMO/c-MET inhibitor overcomes stromal resistance and degrades c-MET to suppress pancreatic cancer.
bioRxiv · Jul 6, 2026 · PreprintCancer Biology