This study identifies budesonide as a drug that inhibits stiffness-induced aggressiveness in pancreatic ductal adenocarcinoma by targeting mechanical cues.

bioRxiv · Jul 20, 2026 · PreprintBioengineering

Targeting the Tumor-Stroma Crosstalk: An AI-Based Virtual Screening Strategy for Dual MET/SMO Inhibitors in Pancreatic Cancer

Michele Roggia, Ugo Chianese, Giorgio Amendola, Valentina Albanese, Cinzia Vetrei, Caterina Ieranò, Crescenzo D’Alterio, Salvatore Di Maro, Fortunato Ciardiello, Floriana Morgillo, Stefania Scala, Lucia Altucci, Delia Preti, Gunnar Schulte, Rosaria Benedetti, , Sandro Cosconati

An AI-identified dual SMO/c-MET inhibitor overcomes stromal resistance and degrades c-MET to suppress pancreatic cancer.

bioRxiv · Jul 6, 2026 · PreprintCancer Biology

Vorinostat (SAHA) alters the skeletal muscle differentiation program

Veronica Sian, Andreas Roos, Andreas Hentschel, Jaakko Sarparanta, Per Harald Jonson, Sérgio Valente, Antonello Mai, Lucia Altucci, Bjarne Udd, Angela Nebbioso, Marco Savarese

This study examines how SAHA affects skeletal muscle differentiation in C2C12 and L6 cells, showing delayed early differentiation and model-dependent changes in gene and protein expression.

bioRxiv · May 30, 2026 · PreprintCell Biology

The inhibitory effects of Remodelin on murine myoblasts differentiation

Veronica Sian, Andreas Hentschel, Paul E. Görs, Jaakko Sarparanta, Andreas Roos, Per Harald Jonson, Karl W. Smith, Swethaa Natraj Gayathri, Ove Eriksson, Antonello Mai, Dante Rotili, Lucia Altucci, Bjarne Udd, Marco Savarese, Angela Nebbioso

This study investigates how Remodelin, a Nat10 inhibitor, affects myoblast differentiation in murine and rat cells, showing impaired myotube formation and maturation.

bioRxiv · Dec 19, 2024 · PreprintCell Biology