Multiplexed cellular and tissue imaging via plasmonic heating activated signal exchange of DNA probes
Ethan Xu, Yanju Chen, Aadhya A Harugeri, Md Yeasin Pabel, Rachel Moor, Elias Joseph Sayour, Ashley Parham Ghiaseddin, Wei David Wei, Fan Hong
This paper introduces PHASER, a method for rapid, multiplexed fluorescence imaging using plasmonic heating to activate DNA thermal probes, achieving 5 targets in a single channel.
bioRxiv · Feb 7, 2026 · PreprintBioengineering