Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer's disease
Jin Hu, Qiang Chen, Hongrui Zhu, Lichao Hou, Wei Liu, Qihua Yang, Huidan Shen, Guolin Chai, Boxin Zhang, Shaoxuan Chen, Zhiyu Cai, Chongxin Wu, Fan Hong, Hongda Li, Sifang Chen, , Wei Mo
This study shows that microglial Piezo1 senses Aβ fibril stiffness, influencing AD pathology by affecting phagocytosis and plaque compaction.
Neuron · Nov 10, 2022Peer-reviewedNeuroscience