An intrinsic cell cycle timer terminates limb bud outgrowth
Joseph Pickering, Constance A. Rich, Holly Stainton, Cristina Aceituno, Kavitha Chinnaiya, Patricia Saiz-López, María A. Ros, Matthew Towers
The paper shows that limb bud outgrowth termination is driven by an intrinsic cell cycle timer, not extrinsic signalling, and identifies a temporal switch in BMP signalling as a key regulator.
eLife · Sep 3, 2018Peer-reviewedDevelopmental Biology