María A. Ros

This study identifies the evolutionary origin of the dorsoventral axis in paired appendages by showing Lmx1b's ancestral role in midline fins and its repurposing through novel regulatory inputs.

The paper develops a limb organoid model to study how signaling centers direct cell fate and spatial organization during limb development.

The paper identifies ancestral dorsal-ventral patterning mechanisms in fish fins and shows evolutionary innovations in their regulation.

This study shows that switching to the p63{beta} isoform can correct AEC syndrome mutations in human keratinocytes without disrupting skin homeostasis.

This study reprograms non-limb fibroblasts into cells with limb progenitor properties using Prdm16, Zbtb16, Lin28, and Lin41.

The paper identifies Fgf signalling's role in triggering a mesodermal timer that controls limb patterning duration using an ex vivo chick wing explant system.

The paper shows that nail tissue, not dorsoventral polarity, is essential for digit tip regeneration, and identifies Lmx1b's role in this process through transcriptomic analysis.

The paper identifies two Lmx1b cis-regulatory modules critical for limb development and shows their disruption in NPS patients with normal coding sequence.

This study identifies two mammalian-specific enhancers upstream of the HoxC gene cluster that regulate Hoxc gene expression in ectodermal organs like hair and nails.

The paper shows that a Sonic hedgehog signaling gradient in chick embryos specifies flight feather patterns and identity through gene expression.

This study investigates the regulatory functions of Sp8 and Sp6 in limb bud ectoderm development using ChIPmentation-seq and RNA-seq, revealing their distinct and cooperative roles in limb patterning.

The paper investigates how mutual repression between Gli3 and Hox13 genes determines the anterior-posterior asymmetry of the autopod, explaining digit 1 agenesis in Hoxa13 mutants.

The paper shows that limb bud outgrowth termination is driven by an intrinsic cell cycle timer, not extrinsic signalling, and identifies a temporal switch in BMP signalling as a key regulator.