Holly Stainton

The paper identifies Fgf signalling's role in triggering a mesodermal timer that controls limb patterning duration using an ex vivo chick wing explant system.

The paper compares wing development in quail and chick to show that developmental timing, controlled by retinoic acid, dictates skeletal pattern expansion differences between species.

The paper shows that limb bud outgrowth termination is driven by an intrinsic cell cycle timer, not extrinsic signalling, and identifies a temporal switch in BMP signalling as a key regulator.