Fragment Screening and Structure-Guided Development of Heparanase Inhibitors Reveals Orthosteric and Allosteric Inhibition
Lani J. Davies, Cassidy Whitefield, H. Kim, Christoph Nitsche, Colin J. Jackson, Rebecca L. Frkic
This study uses fragment-based drug design to identify novel heparanase inhibitors, resulting in compounds with improved potency for potential therapeutic applications.
ACS Medicinal Chemistry Letters · Feb 3, 2026Peer-reviewedBiochemistry