PhysiologyEMBO ReportsPeer-reviewed
E4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression
Fernando Valdivieso Rivera, Vanessa de Oliveira Furino, Carlos Eduardo Pinheiro Leher…·Carlos H. Sponton
This study identifies E4BP4 as a transcriptional repressor that prevents obesity-induced mitochondrial fragmentation in brown fat by inhibiting ceramide synthesis, improving glucose homeostasis without weight loss.
DOI 10.1038/s44319-026-00826-0