Licio Augusto Velloso

This study identifies E4BP4 as a transcriptional repressor that prevents obesity-induced mitochondrial fragmentation in brown fat by inhibiting ceramide synthesis, improving glucose homeostasis without weight loss.

This study shows CETP expression in female mice increases body metabolism under cold exposure and thermoneutrality, leading to a leaner phenotype through enhanced BAT activity and muscle metabolism.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

This study identifies transcriptional differences between resident and recruited hypothalamic microglia in diet-induced obesity, showing that CXCR3-expressing recruited cells protect against metabolic dysfunction.

TopoMetry learns and evaluates the latent geometry of single-cell data, preserving structure better than standard methods and revealing hidden biological signals.

The paper identifies Tril as a mediator of high-fat diet effects in POMC neurons, showing that its knockdown reduces adiposity and increases leptin responsiveness in the hypothalamus.