Vincent Piras

The paper reveals that CTCF binding at TAD boundaries is modular and clustered, challenging existing models of loop extrusion blocking and highlighting a complex code for TAD structure and function.

The paper investigates how CTCF modulates sub-TAD structure at imprinted domains in mice, affecting gene activity through allele-specific binding.

The paper develops a polymer model to analyze chromatin organization changes during differentiation, finding synchronous compaction/decompaction of TADs and secondary structures in 5C data.

The paper analyzes transcriptome-wide expression patterns in Saccharomyces cerevisiae biofilm strains, finding global regulatory stability despite local expression changes.