Andrea Papale

Insulation between adjacent TADs is controlled by the width of their boundaries through distinct mechanisms

The paper investigates how TAD boundary width influences insulation between adjacent TADs, showing that wider boundaries reduce inter-TAD contacts and enhance insulation.

A complex CTCF binding code defines TAD boundary structure and function

The paper reveals that CTCF binding at TAD boundaries is modular and clustered, challenging existing models of loop extrusion blocking and highlighting a complex code for TAD structure and function.

High changing curvature regions detect chromatin enrichment in single cell data

This study identifies high changing curvature (HCC) regions in Hi-C data that correlate with gene expression and CTCF density, showing cell-to-cell variability.

Chromatin phase separated nanoregions regulated by cross-linkers and explored by single particle trajectories

The paper studies how cross-linkers generate chromatin phase separated nanoregions and quantifies their impact on molecular access using single particle trajectories.

Chromatin stability generated by stochastic binding and unbinding ofcross-linkers at looping sites revealed by Markov models

The paper uses Markov models to analyze how chromatin loops remain stable through stochastic binding and unbinding of cross-linkers, showing that a positive feedback mechanism ensures loop stability.