Author

A. Geoffrey Lyle

University of California, Santa CruzORCID 0000-0002-3435-526XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:variant calling· 1

Frequent Co-Authors

David H. HaussleriD· 2 shared Drew ThompsoniD· 2 shared Ellen Towle KephartiD· 2 shared Holly C. BealeiD· 2 shared Isabel Bjork· 2 shared Katrina LearnediD· 2 shared Lauren SandersiD· 2 shared Olena M. VaskeiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

David H. HausslerORCID

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2 papers

Recent·Most cited

Genetic & Genomic Medicinenpj Precision OncologyPeer-reviewedMar 21, 2025

Comparative analysis of RNA expression in a single institution cohort of pediatric cancer patients

Yvonne A. Vasquez, Holly C. Beale, Lauren Sanders…·Olena M. Vaske

The paper evaluates the CARE pipeline for identifying druggable targets in pediatric cancers using RNA-Seq data from 33 patients, showing 94% of cases had clinically significant findings.

1 citation

humanbulk RNA-seq

GenomicsGigaSciencePeer-reviewedMar 1, 2021

The case for using Mapped Exonic Non-Duplicate (MEND) read counts in RNA-Seq experiments: examples from pediatric cancer datasets

Holly C. Beale, Jacquelyn M. Roger, Matthew A. Cattle…·Olena M. Vaske

The paper evaluates the informativeness of reads in bulk RNA-Seq datasets and recommends using MEND reads for accurate gene expression quantification in pediatric cancer studies.

8 citations

humanbulk RNA-seq