Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise
Aliza B. Rubenstein, Gregory R. Smith, Zidong Zhang, Xi Chen, Toby L. Chambers, Frederique Murielle Ruf-Zamojski, Natalia Mendelev, Wan Sze Cheng, Michel Zamojski, Mary Anne S. Amper, Venugopalan D. Nair, Andrew R. Marderstein, Stephen B. Montgomery, Olga G. Troyanskaya, Elena Zaslavsky, , Stuart C. Sealfon
The paper uses single-nucleus multiome sequencing to analyze gene regulatory changes in human skeletal muscle after endurance exercise, identifying fiber-type specific regulatory programs and transcription factor networks.
Genome Research · Jul 1, 2025Peer-reviewedGenomics