Frederique Murielle Ruf-Zamojski

The paper uses single-nucleus multiomics to study pituitary cell changes during the mouse estrous cycle, finding stage-dependent gene regulatory circuits and validated ETS2-driven gene expression patterns.

The paper identifies four activin-sensitive enhancers upstream of the murine Fshb gene, showing differential regulation by SMAD2/3 and FOXL2 in gonadotropes.

The paper creates a large-scale Consensus Pituitary Atlas to improve reproducibility and enable marker discovery and analysis in pituitary research.

The paper uses single-nucleus multiome sequencing to analyze gene regulatory changes in human skeletal muscle after endurance exercise, identifying fiber-type specific regulatory programs and transcription factor networks.

This paper provides a comprehensive guide for quality control metrics and mitigation strategies for 11 epigenetics and transcriptomics assays to improve exposure signature discovery.

SPEEDI automates single-cell multi-omics analysis by integrating data, inferring batches, and labeling cell types without user input, improving reproducibility and accessibility.

The paper introduces CREMA, a framework for mapping cis-regulatory circuits using single-cell multiome data without peak-calling, and validates it using mouse pituitary data.