Author

Kevin P. Guay

University of Massachusetts AmherstORCID 0000-0002-3468-942XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Daniel N. HebertiD· 1 shared Lila M. GieraschiD· 1 shared Owen A. Hurlbut LeskiD· 1 shared Robert V. WilliamsiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

Daniel N. HebertORCID

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1 paper

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedOct 1, 2026

The cysteine-rich domain of SEP15, a selenoprotein co-chaperone of the ER chaperone, UDP-glucose:glycoprotein glucosyltransferase, adopts a novel fold

Robert V. Williams, Kevin P. Guay, Owen A. Hurlbut Lesk…·Lila M. Gierasch

The paper determines the structure of the cysteine-rich domain of SEP15 using AlphaFold and NMR, revealing a novel helical fold stabilized by disulfide bonds.

DOI 10.1016/j.jbc.2026.113629

protein structuredeep learning

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